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Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity

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This research was supported by grants from the Beijing Municipal Health Commission High-level Public Health Technical Talent Construction Program (Discipline backbone-01-010, to XZ), the Beijing Natural Science Foundation (52222020, to XQ), and the State Key Laboratory of Integrated Management of Pest Insects and Rodents (IPM2305, to XZ)

The proteins TDP-43 and FUS are involved in managing RNA, and influencing thousands of genes, and their dysfunctioning severely impacts RNA splicing, stability, and export